Mutation Spectrum Induced by Dihydropyrazines in Escherichia coli
نویسندگان
چکیده
منابع مشابه
Adaptive mutation in Escherichia coli.
In 1988 John Cairns, Julie Overbaugh, and Stephan Miller published a paper entitled “The origin of mutants,” in which they suggested that bacteria could choose which mutations to make (11). Shortly thereafter, Cairns and I began collaborating on a National Science Foundation-funded project to investigate the genetic basis of what was popularly called “directed mutation” (although at the time we...
متن کاملSpectrum of cisplatin-induced mutations in Escherichia coli.
Using a forward-mutation assay based on the inactivation of the tetracycline-resistance gene located on plasmid pBR322, we have determined the mutation spectrum induced in Escherichia coli by cisplatin [cis-diamminedichloroplatinum(II)], a widely used antitumor drug. Cisplatin is known to form mainly intrastrand diadducts at ApG and GpG sites. We found that cisplatin efficiently induces mutatio...
متن کاملFecal carriage of Escherichia coli harboring extended-spectrum beta-lactamase (ESBL) genes by sheep and broilers in Urmia region, Iran
Background: There is a growing concern on the impact of the presence of extended-spectrum β-lactamase (ESBL) producing Escherichia coli isolated from animals on public health. OBJECTIVES: The aim of this study was to investigate the presence of three classes of ESBL genes in E. coli isolates from sheep and broilers at a slaughter in Urmia region, Iran. METHODS: A total of 111 E. coli isolates w...
متن کاملRebuttal: adaptive mutation in Escherichia coli (Foster).
If mutations arose in nongrowing cells, as proposed in Foster’s paper (1), then stress-induced mutagenesis would seem inescapable. The plated population certainly grows very little. However, no evidence is provided that reversion occurs in this population and no effort is made to counter evidence to the contrary (see below)—that mutations actually arise in cells growing under selection within d...
متن کاملMutation affecting plasmolysis in Escherichia coli.
A temperature-sensitive mutant of Escherichia coli is described that at the restrictive temperature has lost the ability to plasmolyze. The mutation is located near pyrF.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2006
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.29.17